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Example Figures

Fig. 4. Relationship between voltage-clamped membrane potential and histamine-induced current recorded with 3-M KCl microelectrodes. A: selected current traces are shown from an unligated motor neuron (anterior cell 2) at various Vh (mV) indicated above each trace. B: data from 5 different experiments such as that in A were averaged. The dashed line was drawn by eye, and its intersection with the abscissa represents the mean reversal potential of the histimine-evoked current (30 mV; n = 5).

J Neurophysiol 68: 915, 1992

Fig. 1. Calcium channel currents in embryonic mouse motoneurons. Test depolarization to the indicated potentials (in mV) were applied from the holding potential (80 mV). Currents were measured from a single cell bathed first in an external solution containing 10 mM Ca2+ (A) and then in one containing 10 mM Ba2+ (B).

J Neurophysiol 68: 8592, 1992

Fig. 5. Effects of nonspecific glutamate receptor antagonist kynurenate on granule cell PSC. A: PSCs are averages of 4 records from the same granule cell held at 30 mV and stimulated at constant intensity and frequency. Top: PSC in control medium. Middle: PSC after perfusion of 1 mM kynurenate from control PSC. Bottom: digital subtraction of PSC in kynurenate from control PSC. B: same experiment as in A, at a holding potential of 0 mV.

J Neurophysiol 68: 197212, 1992

Fig. 8. Top: relationship between current threshold intensity and duration to juxtasomal current pulse (JSCP) stimulation (left, chronaxie = 0.14 ms) and axonal stimulation (right, chronaxie = 0.55 ms) for a descending corticofugal neuron of layer 6 (CF-6). Bottom: relationship axonal conduction velocity and chronaxie obtained by JSCP stimulation (left) and axonal stimulation (right). Each open circle represents the measure from an individual neuron, and only neurons in which measures were taken from both stimulus locations are shown.

J Neurophysiol 68: 605 619, 1992

Fig. 2. Examples of 3 kinds of temporal adaptation pattern (TAP) behavior. AC: 2 different response of a single unit. Left and right columns: a response to a BF tone and the response of the same unit to a two-tone stimulus, respectively. Within each pair of columns, the panels at right show PSTHs computed from responses to short tone or tone pair bursts (50 ms; both tone and tone pair bursts referred to as STBs). In this and all other figures, unless otherwise indicated, panels at left show the mean ISI (μ) and its SD (σ) computed as functions of time through the response. Plots of μ and σ are truncated at 40 ms poststimulus onset to remove end-effect artifacts (described in Young et al. 1988). A: a case in which there is no difference between the TAP of the BF and the two-tone response (both are sustained). B: TAP changes from sustained (BF tone response) to slowly adapting (two-tone response). C: TAP changes from slowly adapting (BF tone response) to transiently adapting (two-tone response). These examples are examined in greater detail in Figs. 5, 8, and 11, respectively.

J Neurophysiol 68: 124 143, 1992

Fig. 4. Amiloride selectively reduces T current in embryonic mouse motoneurons. A: T current recorded from a cell before (A) and during (B) exposure to 2 mM amiloride and after washout of the drug (C). B: HVA calcium currents recorded before and during exposure to 2 mM amiloride. External solution contained 10 mM Ca2+.

J Neurophysiol 68: 8592, 1992

Fig. 3. Recording sites. This schematic shows the electrode penetration sites for the cell responses recorded in this study. Electrode locations from 5 hemispheres (2 left and 3 right) are superimposed on this drawing of a right hemisphere. CS, central sulcus; AS, arcuate sulcus; PCD, precentral dimple; M, medial; A, anterior.

J Neurophysiol 68: 528541, 1992

Fig. 8. Interictal bursts and spontaneous EPSCs induced by high potassium. Elevation of [K+]o from 5.0 to 8.5 mM (solid line) induces interictal burst firing. The addition of elevated potassium also results in a robust inward current (35 pA). B: continuous trace of 1.7 s before the appearance of a single action current (arrow). EPSC (*) frequency was 1.8 Hz. C: after exposure to 8.5 mM K+, the incidence of EPSC activity increases before the onset of the interictal burst (arrow). EPSC activity was 4.2 Hz in a 600-ms period recorded immediately before the onset of the interictal event. In a similar time period recorded immediately before the onset of the interictal event, the frequency rose to 14.7 Hz. D and E: amplitude histograms (bin size 5 pA) demonstrate that although the elevation of extracellular potassium increases the frequency of EPSC activity, it does not affect the mean amplitude.

J Neurophysiol 68: 1527, 1992

Fig.2. Number of synapses per mm3 of area in 4γ in control and in experimental hemispheres. Bars, mean SE. Analysis of variance (ANOVA): *P < 0.01; **P < 0.001.

J Neurophysiol 68: 295308, 1992

Fig. 6. Effect of the dihydropyridine agonist (+)-SDZ 202-791 on I-V relationships of mouse motoneuron calcium channel currents. Sustained (A) and transient (B) components of currents from 1 cell in control solution (p), 100 nM (+)-SDZ 202-791 (u), 500 nM (+)-SDZ 202-791 () and 1 mM (+)-SDZ 202-791 (r). Transient and sustained components measured as described in legend to Fig. 2. Charge carrier was 10 mM Ba2+.

J Neurophysiol 68: 8592, 1992

Fig. 6. Relationship between threshold to juxatasomal current pulse stimulation and the amplitude of the extracellular spike. l, neurons with initially positive-going action potentials.

J Neurophysiol 68: 605619, 1992

Fig.4. BF SD-vs.-mean ISI plots for 6 units, all of which have several lower rate (mean ISI >5 ms) BF data points. Units in AC are regular choppers; units in DF are irregular choppers. Regression lines: A, y = 0.45x 0.93, R2 = 0.989; B, y = 0.43x 1.00, R2 = 0.984; C, y = 0.44x 0.72, R2 = 0.988; D, y = 0.32x 0.32, R2 = 0.949; E, y = 0.79x 1.15, R2 = 0.990; F, y = 0.80x 1.04, R2 = 0.998. ISI CVs at 30 dB are threshold for AF: 0.16, 0.18, 0.22, 0.41, 0.44, 0.45. BFs and unit numbers appear on figure.

J Neurophysiol 68: 124143, 1992

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last edited 08/7/03